![]() The downward shift in salience of natural reward relative to drug reward may represent a crucial tipping point leading to the loss of control over drug use that is characteristic of addiction. During the process of hedonic dysregulation, chronic use of drugs of abuse, including opioids, produces neurobiological alterations that increase the incentive salience of drug-related cues ( 6), resulting in heightened drug cue-reactivity and craving while, at the same time, decreasing sensitivity to natural reward derived from homeostatic goal attainment ( 7). Consequently, addiction involves a process of hedonic dysregulation, in which the motivation to obtain natural rewards is reorganized around seeking drug-associated reward and the desire to alleviate aversive states (e.g., stress and pain) ( 5). These models posit that prolonged opioid use may shift hedonic set points in corticostriatal circuitry mediating reward and disrupt capacity to proactively regulate responses to emotional stimuli. This series of randomized experiments provide the first neurophysiological evidence that an integrative behavioral treatment can remediate hedonic dysregulation among chronic opioid users.Īllostatic models have been advanced to explicate the downward spiral leading to opioid misuse and OUD ( 3, 4). Increased positive affective responses to natural reward cues were associated with decreased craving and mediated MORE’s therapeutic effects on opioid misuse. MORE was associated with decreased opioid cue-reactivity and enhanced capacity to regulate responses to opioid and natural reward cues. Before and after 8 weeks of MORE or a support group control, prescription opioid users ( N = 135) viewed opioid and natural reward cues while an electroencephalogram biomarker of target engagement was assessed. Here, we assessed whether a cognitive intervention for addiction, Mindfulness-Oriented Recovery Enhancement (MORE), could restructure reward responsiveness from valuation of drug-related reward back to valuation of natural reward. Addiction neuroscience models posit that recurrent drug use increases reactivity to drug-related cues and blunts responsiveness to natural rewards, propelling a cycle of hedonic dysregulation that drives addictive behavior.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |